The bcr-abl fusion protein is a well-known example of an oncogenic fusion protein, and is considered to be the primary oncogenic driver of chronic myelogenous leukemia. Naturally occurring fusion proteins are commonly found in cancer cells, where they may function as oncoproteins. Chimeric mutant proteins occur naturally when a complex mutation, such as a chromosomal translocation, tandem duplication, or retrotransposition creates a novel coding sequence containing parts of the coding sequences from two different genes. Chimeric or chimera usually designate hybrid proteins made of polypeptides having different functions or physico-chemical patterns. Recombinant fusion proteins are created artificially by recombinant DNA technology for use in biological research or therapeutics. Translation of this fusion gene results in a single or multiple polypeptides with functional properties derived from each of the original proteins. A chimeric protein including two subunits and a linker protein synthesized via recombinant fusion technology.įusion proteins or chimeric (kī-ˈmir-ik) proteins (literally, made of parts from different sources) are proteins created through the joining of two or more genes that originally coded for separate proteins.
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